The common things that you want to do, without going as far has hacking Venabili's code, is define your own key layers and macros.
Changing what the keyboard does is quick and simple, you won't even need to unplug it, and making small incremental tweaks every time you think of a way to make your typing a little bit faster and/or comfortable is highly encouraged!
The process goes like so:
venabili.c with your own layers and macros
Recompile the firmware
Enter flash mode
Flash the new firmware